MI 822

Immunity, Infection and Disease

 Course Syllabus 2007

Course Director,

R. J. Jacob

 

 

 

 

 

 Contents*

 

 

1.         Course Schedule

 

2.         Course Description, Objectives, Grading, and Resources

 

3.         Instructors and Office Hours and Communications

 

4.         Membership of Small Groups (inserts to be provided)

 

5.         Lecture Objectives (electronic version only)

 

6.         Laboratory Manual

 

 

* Most of this content is also provided at the course Blackboard site http://elearning.uky.edu

 

Acknowledgments:

It is appropriate to thank members of the University of Kentucky College of Medicine faculty for their input to this document.  In particular the faculty of Microbiology, Immunology, and Molecular Genetics in its preparation. 

 

 

©2007 R. J. Jacob (BJ2)

 

 

 

 

 

 

I:/. . ./IID/iid syllabus 2007

Immunity, Infection and Disease

MI 822 Block Schedule 2007

 

WEEK 1:  8/6 - 8/10

 

 

 

Mon 8/6

 

Tues 8/7

 

Wed 8/8

 

Thurs 8/9

 

Fri 8/10

 

8

A

M

 

Intro. to

The Course

 

Jacob

 

Cells, Organs

 cell biol. & histo.

 

Cohen

 

Ag/Antibody

(Ab) interaction

concepts

Cohen

 

Complement

Systems I

 

Cohen

Outcomes of acute inflammation/

Chronic inflammation

 

Murphy

 

9

A

M

 

Infectious Diseases:

Show & Tell

Greenberg

 

 

Cells, organs - maturation & recirculation

Cohen

 

Ag/Ab  Interaction

diag. tools

 

Cohen

 

Complement

Systems II

 

Cohen

 

 

 

10

A

M

 

Immune System Overview and Clinical Manifestations

Cohen

 

Antigens(Ags) & antigenic determs.

 

Kaetzel

 

Cell &

Tissue Injury

 

Murphy

 

 

Acute Inflammatory Response I

Murphy

 

 

11

A

M

 

 

Immunoglobulins - struc. & function

 

Kaetzel

 

 

Acute Inflammatory Response II

 

Murphy

 

 

 

WEEK 2:  8/13 - 8/17

 

 

 

Mon 8/13

 

Tues 8/14

 

Wed 8/15

 

Thurs 8/16

 

Fri 8/17

 

8

A

M

 

 

MHC 1 - struc. & function

 

Cohen

 

Humoral immune response III

 

Kaetzel

 

 

Mucosal Immune Response

 

Kaetzel

 

 

Immunological tolerance

 

Cohen

   

9

A

M

 

Repair & wound healing

 

Murphy

 

MHC 2 - mol. biol.

 

 

Cohen

 

Cellular immune response I

 

Cohen

 

Transplantation immunology

 

Cohen

 

 

Autoimmunity

 

 

Cohen

 

10

A

M

 

Ab biochem. & mol. biol.

 

Kaetzel

 

 

Humoral immune response I

 

Kaetzel

 

Cellular immune response II

 

Cohen

 

Tumor immunity

 

 

Cohen

 

Autoimm.

pathology

 

Jennings

 

 

11

A

M

 

TCR - bioch. & mol. biol.

 

Kaetzel

 

Humoral immune response II

 

Kaetzel

 

 

Innate immunity

 

 

Kaplan/Kaetzel

 

Mechs. Immune injury

 

Jennings

 

Clinical Correlation:

 

TBA

Immunity, Infection and Disease

MI 822 Block Schedule 2007

 

WEEK 3:  8/20 - 8/24

 

 

 

Mon 8/20

 

Tues 8/21

 

Wed 8/22

 

Thurs 8/23

 

Fri 8/24

 

8

A

M

 

DC #1:

Tissue transplant/

rejection

 

Path./Imm.

 

General Approach

to vaccine development

 

Bondada

 

Clinical Cases

Women's Health:

Autoimmune Inflammatory Rheumatic Diseases

 

 

 

RNA viruses, gen.;

 

Jacob

 

Viral-host interactions:

 

Cohen

 

 

9

A

M

 

 

 

 

 

Congen. & acquired

Immunodeficiency

 

Cohen

Crofford

 

Viral Genetics

 

Telling

 

 

HIV/AIDS I

 

Greenberg

 

10

A

M

 

Host response

to extracellular pathogens

 

Cohen

 

DC #2

Autoimmunity

 

 

Intro. to Virology

 

Jacob

 

Prions & Diseases

 

 

Telling

 

HIV/AIDS II

Patient & Clinical Correlates

 

Greenberg

 

11

A

M

 

 

 

DNA viruses, gen.

 

Jacob

 

Viral Oncology

 

Garraghty

 

Respiratory Viral Pathogens=RVP

WEEK 4:  8/27– 8/31

 

 

 

Mon 8/27

 

Tues 8/28

 

Wed 8/29

 

Thurs 8/30

 

Fri 8/31

 

8

A

M

 

 

EXAM 1

 

Immunology

 

 

RVP:

Influenza and other resp. viruses

 I

J. McCormick          

 

EVP:

DC #3

Hepatitis

 

Human Herpeviruses Lecture I

 

Jacob

 

Viral Latency &

Persistence

 

Jacob

 

9

A

M

(Cohen)

 

           RVP:

Influenza and other resp. viruses

II

J. McCormick

 

 

Human

Herpesviruses Lecture II

 

Geraghty

 

DC #4

 

Viral Diseases